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| Company | Type | City | State / Province | Country / Region | |
| Scopely | Mobile | Dundee | Angus | Scotland | |
| Scopely | Publisher | London | London | England | |
| Scopely | Publisher | Mexico City | Mexico City | Mexico | |
| Scopely | Developer | Porto | Grande Porto | Portugal | |
| Scopely | Developer | Quebec City | Quebec | Canada | |
| Scopely | Developer and Publisher | San Francisco | California | United States | |
| Scopely | Publisher | Seoul | Seoul | Republic of Korea | |
| Scopely | Publisher | Shanghai | Shanghai | China | |
| Scopely | Publisher | Singapore | Singapore | Singapore | |
| Scopely | Developer | Tel Aviv | Tel Aviv | Israel | |
| Scopely | Publisher | Tokyo | Tokyo | Japan | |
| Score Studios | Developer | Tokyo | Tokyo | Japan | |
| Scout Game Studios | Developer | San Jose | San Jose | Costa Rica | |
| Screen Burn | Developer | Glasgow | Glasgow | Scotland | |
| Screenput | Developer | Linkoping | Ostergotland | Sweden | |
| Screenwave Media | Online | Philadelphia | Pennsylvania | United States | |
| Screwtape Studios | Developer | Brisbane | Queensland | Australia | |
| SCS Software | Developer | Prague | Bohemia | Czechia | |
| SculptrVR | Extended Reality (XR) | Las Vegas | Nevada | United States | |
| Scumhead | Developer | Phoenix | Arizona | United States | |
| SD Studio (Sony) | Developer | San Diego | California | United States | |
| SDK Games | Extended Reality (XR) | Douala | Littoral | Cameroon | |
| SDP Games | Developer | Lyon | Rhone-Alpes | France | |
| SDPlay | Mobile | Mexico City | Mexico City | Mexico | |
| Sea Monster | Developer | Cape Town | Western Cape | South Africa | |
| Sea Monster Entertainment | Serious Games | Cape Town | Western Cape | South Africa | |
| Seabank Digital Productions | Developer | Melbourne | Victoria | Australia | |
| Seabird Interactive | Developer | Saint Malo | Bretagne | France | |
| Seafloor Games | Developer | Boston | Massachusetts | United States | |
| Seaknot Studios | Developer | Tokorozawa | Saitama | Japan | |
| Sealost Interactive | Extended Reality (XR) | Knoxville | Tennessee | United States | |
| Searching Interactive | Developer | Melbourne | Victoria | Australia | |
| Seashell Studio | Developer | Queretaro | Queretaro | Mexico | |
| Seasun Games | Developer | San Mateo | California | United States | |
| Seattle Indies | Organization | Seattle | Washington | United States | |
| Seaven Studio | Developer | Lille | Nord-Pas-de-Calais-Picardie | France | |
| Second Avenue Learning | Developer | Rochester | New York | United States | |
| Second Breath Interactive | Microstudio | Chicago | Illinois | United States | |
| Second Dinner | Developer | Irvine | California | United States | |
| Second Half Games | Developer | Remote | Remote | Remote | |
| Second Impact Games | Developer | Brighton | East Sussex | England | |
| Second Maze Studios | Publisher | Amsterdam | Noord-Holland | Netherlands | |
| Second Quest | Developer | Bengaluru | Karnataka | India | |
| Second Star Games | Developer | Warrington | Cheshire | England | |
| Secret 6 | Developer | Madrid | Madrid | Spain | |
| Secret 6 | Developer | Manila | Metropolitan Manila | Philippines | |
| Secret 6 | Developer | San Francisco | California | United States | |
| Secret Base | Developer | Singapore | Singapore | Singapore | |
| Secret Door (Dreamhaven) | Developer | Irvine | California | United States | |
| Secret Exit | Developer | Helsinki | Uusimaa | Finland | |
| Secret Item Games | Developer | Lünen | North Rhine-Westphalia | Germany | |
| Secret Lab | Mobile | Hobart | Tasmania | Australia | |
| Secret Mode | Publisher | Leamington Spa | Warwickshire | England | |
| Secret Plan Games | Microstudio | Victoria | British Columbia | Canada | |
| Secret Portal | Extended Reality (XR) | Boston | Massachusetts | United States | |
| Secret Sauce | Publisher | London | London | England | |
| Section 9 Interactive | Developer | Malmo | Scania | Sweden | |
| Sector-K Games | Developer | Orlando | Florida | United States | |
| Sectordub | Developer | London | London | England | |
| Sedleo | Developer | Pistoia | Toscana | Italy | |
| See More Games | Microstudio | Lane Cove North | New South Wales | Australia | |
| Seed Studio | Developer | Taipei | Taiwan | Taiwan | |
| Seedy Eye | Developer | Owensboro | Kentucky | United States | |
| Seeker Entertainment | Developer | Los Angeles | California | United States | |
| Seemingly Pointless | Developer | Los Angeles | California | United States | |
| Sega Amusements USA | Developer | Elk Grove Village | Illinois | United States | |
| Sega Australia | Publisher | Sydney | New South Wales | Australia | |
| Sega Europe | Publisher | Brentford | Middlesex | England | |
| Sega Gesellschaft für Videospiele mbH | Publisher | Dusseldorf | North Rhine-Westphalia | Germany | |
| Sega Holdings | Publisher | Tokyo | Tokyo | Japan | |
| Sega Korea | Publisher | Seoul | Seoul | Republic of Korea | |
| Sega Networks | Mobile | San Francisco | California | United States | |
| Sega of America | Publisher | Burbank | California | United States | |
| Sega of America | Publisher | Irvine | California | United States | |
| SEGA Studio Operations Sofia | Publisher | Sofia | Sofia | Bulgaria | |
| Seismic Games | Developer | Los Angeles | California | United States | |
| Seismic Squirrel | Developer | Issaquah | Washington | United States | |
| SeithCG | Developer | Saint Genis des Fontaines | Languedoc-Roussillon-Midi-Pyrenees | France | |
| Seize Studios | Developer | Brasilia | Federal District | Brazil | |
| Sekai Project | Publisher | Norwalk | California | United States | |
| Self Hunter Studio | Developer | Los Angeles | California | United States | |
| Selkie Harbor | Developer | Valencia | Valencia | Spain | |
| Selva Interactive | Developer | Guatemala City | Guatemala | Guatemala | |
| Semaphore | Developer | Riyadh | Riyadh | Saudi Arabia | |
| semiwork | Developer | Uppsala | Uppland | Sweden | |
| SenAm Games | Developer | Munich | Bayern | Germany | |
| Senatis | Developer | Boca Raton | Florida | United States | |
| Senopi | Health | Zürich | Zürich | Switzerland | |
| Sense Arena | Extended Reality (XR) | Woburn | Massachusetts | United States | |
| SenseGames | Developer | Chengdu | Sichuan | China | |
| Senshi Labs | Organization | Makati City | National Capital Region | Philippines | |
| Sentience Game Studio | Developer | Seoul | Seoul | Republic of Korea | |
| Sentiment Games | Developer | Berlin | Berlin | Germany | |
| Sentinel Games | Developer | Austin | Texas | United States | |
| Separuh Interactive | Developer | Bandung | West Java | Indonesia | |
| September Games | Microstudio | Vassa | Ostrobothnia | Finland | |
| Sequel Games | Mobile | Stockholm | Stockholm | Sweden | |
| Serafini Productions | Developer and Publisher | Tokyo | Tokyo | Japan | |
| Serbian Games Association (SGA) | Organization | Belgrade | Belgrade | Serbia | |
| Serenity Forge | Developer and Publisher | Boulder | Colorado | United States | |
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